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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Quercetin, Fluorouracil
Phytochemical Name Quercetin (PubChem CID: 5280343 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Fluorouracil
Adverse Reactions Application site erythema, application site pruritus. This was inferred hot nature anticancer drug.
Recommendations Cold: Pueraria thomsonii; Bupleurum scorzonerifolium; Pueraria thomsonii; Pueraria edulis
Reference Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019.　　ref_link
Combination Pair ID: 976
Ref_1
Pair Name Quercetin, Fluorouracil
Disease Info [ICD-11: 2B90] Colon cancer Investigative
In Vitro Model HT-29 Colon adenocarcinoma Homo sapiens (Human) CVCL_0320
In Vivo Model Rats were assigned to two groups. The 5-FU/quercetin group received intraperitoneal quercetin (10 mg/kg) and the Tween was injected to the control group for 14 consecutive days. On the 15th day, both groups received 50 mg/kg of 5-FU.
Result Interaction of quercetin and 5-fluorouracil: cellular and pharmacokinetic study
Reversing Drug Resistance
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Combination Pair ID: 979
Ref_2
Pair Name Quercetin, Fluorouracil
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression HMOX1 hsa3162
Down-regulation Expression NFE2L2 hsa4780
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
Result Our results suggest that Que reverses 5-FU resistance in CC cells via modulating the Nrf2/HO-1 pathway.
03. Reference
No. Title Href
1 Interaction of quercetin and 5-fluorouracil: cellular and pharmacokinetic study. Toxicol Mech Methods. 2023 Nov;33(6):502-511. doi: 10.1080/15376516.2023.2188928. Click
2 Quercetin reverses 5-fluorouracil resistance in colon cancer cells by modulating the NRF2/HO-1 pathway. Eur J Histochem. 2023 Aug 7;67(3):3719. doi: 10.4081/ejh.2023.3719. Click
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